A POLYNUCLEOTIDE COENZYME OF OXIDATIVE PHOSPHORYLATION
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چکیده
منابع مشابه
A requirement for coenzyme A in oxidative phosphorylation.
Experiments have shown that oxidative phosphorylation by aged, or otherwise damaged, mitochondria may be restored by additions of ATP and DPN (l), by combinations of ATP, DPN and Mn++ (2) or by bovine serum albumin (3). In the latter instance albumin apparently acts by binding an inhibitory protein, mitochrome, which is released by the mitochondria upon aging. More recently Cooper and Lehninger...
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Introduction Thyroid hormones (TI Is) affect cellular metabolism via two different pathways. The first one is the socalled nuclear, long-term effect: there the TI I binds to a nuclear receptor and regulates the transcription o f multiple cellular proteins f 11. The other pathway, the short-term extranuclear pathway, is less w d l defined and could in principle be similar to other short-term sig...
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Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they show very potent activities. The most poten...
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was proportional to the acidity of the imidazole -NH group. Tetrachloro-2trifluoromethylbenzimidazole was the most active (50% uncoupling of oxidative phosphorylation at 7-9 x 10-8M, pK5.04). Nitro-substituted analogues were less active than predicted from pK considerations or from partition-coefficient measurements. 3. Introduction of an -NH2 or -CO2H substituent caused a loss of uncoupling ac...
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Isolated mitochondria will catalyze many of the oxidative reactions observed with intact cells. However, such enzymatic activity may be only an approximation of the in vivo metabolism. Metabolic studies of reconstituted cells have utilized washed residues which represent simultaneously isolated cellular components (l), the recombination of cellular components in vitro (2), and special media whi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70588-7